Abstract

Photoacoustic microscopy is predominantly sensitive to optical absorption, while optical coherence tomography relies on optical backscattering. Integrating their complementary contrasts can provide comprehensive information about biological tissue. We have developed a dual-modality microscope that combines the two for studying microcirculation. Three-dimensional imaging of microvasculature and its local environment has been demonstrated at micrometer-order resolution using endogenous contrast in vivo.

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History
Original Manuscript: July 2, 2009
Manuscript Accepted: August 13, 2009
Revised Manuscript: August 11, 2009
Published: August 31, 2009

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Author Affiliations

Li Li, Konstantin Maslov, Geng Ku, Lihong V. Wang

Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, 1 Brookings Drive, Campus Box 1097, St. Louis, Missouri 63130, USA

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