Abstract

Spatially resolved reflectance measurements can be used to characterize the depth-resolved optical properties of superficial tissues. However, until now, rapid acquisition of multiwavelength data has been hindered by multiplexing problems. We report on a novel multiwavelength laminar optical tomography system capable of acquiring data from multiple source-detector separations at three wavelengths simultaneously. Such data can allow in vivo depth-resolved spectroscopic imaging of absorbers, such as oxy- and deoxyhemoglobin, or of multiple fluorophores, that is unaffected by motion artifacts at frame rates exceeding 100 Hz. The system design and phantom validation studies are presented.

© 2008 Optical Society of America

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History
Original Manuscript: July 29, 2008
Manuscript Accepted: September 11, 2008
Published: November 14, 2008

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Author Affiliations

Sean A. Burgess, Matthew B. Bouchard, Baohong Yuan, Elizabeth M. C. Hillman

Columbia University

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