Transillumination fluorescence imaging in mice using biocompatible upconverting nanoparticles
Optics Letters, Vol. 34, Issue 17, pp. 2566-2568 doi:10.1364/OL.34.002566
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- OCIS Codes:
- (110.0110) Imaging systems : Imaging systems
- (170.0170) Medical optics and biotechnology : Medical optics and biotechnology
- (170.7050) Medical optics and biotechnology : Turbid media
- (190.3970) Nonlinear optics : Microparticle nonlinear optics
- (190.7220) Nonlinear optics : Upconversion
Medical Optics and Biotechnology
Citation
Claudio Vinegoni, Daniel Razansky, Scott A. Hilderbrand, Fangwei Shao, Vasilis Ntziachristos, and Ralph Weissleder, "Transillumination fluorescence imaging in mice using biocompatible upconverting nanoparticles," Opt. Lett. 34, 2566-2568 (2009)
http://www.opticsinfobase.org/VJBO/abstract.cfm?URI=ol-34-17-2566
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We report on a systematic study of upconverting fluorescence signal generation within turbid phantoms and real tissues. An accurate three-point Green's function, describing the forward model of photon propagation, is established and experimentally validated. We further demonstrate, for the first time to our knowledge, autofluorescence-free transillumination imaging of mice that have received biocompatible upconverting nanoparticles. The method holds great promise for artifact-free whole-body visualization of optical molecular probes.
© 2009 Optical Society of America
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History
Original Manuscript: April 10, 2009
Manuscript Accepted: June 30, 2009
Revised Manuscript: June 22, 2009
Published: August 19, 2009
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Author Affiliations
Massachusetts General Hospital
Technical University of Munich and Helmholtz Center Munich
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