OSA's Digital Library

Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 4, Iss. 3 — Mar. 2, 2009

Coherent anti-Stokes Raman scattering microscopy for quantitative characterization of mixing and flow in microfluidics

Dawn Schafer, Michiel Müller, Mischa Bonn, David W.M. Marr, Jan van Maarseveen, and Jeff Squier  »View Author Affiliations

Optics Letters, Vol. 34, Issue 2, pp. 211-213 (2009)

View Full Text Article

Enhanced HTML    Acrobat PDF (237 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



We present an optical, noninvasive and label-free approach to characterize flow profiles in microfluidic devices. Coherent anti-Stokes Raman scattering signals were used to map the mass transport in a microfluidic device that was then related back to the local flow rate of dilute solutes having constant fluid properties. Flow characterization was demonstrated in two common types of microfluidic devices, polydimethylsiloxane/glass square channels and wet-etched glass tapered channels.

© 2009 Optical Society of America

OCIS Codes
(300.6230) Spectroscopy : Spectroscopy, coherent anti-Stokes Raman scattering
(180.4315) Microscopy : Nonlinear microscopy

ToC Category:

Original Manuscript: August 11, 2008
Revised Manuscript: November 20, 2008
Manuscript Accepted: November 26, 2008
Published: January 14, 2009

Virtual Issues
Vol. 4, Iss. 3 Virtual Journal for Biomedical Optics

Dawn Schafer, Michiel Müller, Mischa Bonn, David W. M. Marr, Jan van Maarseveen, and Jeff Squier, "Coherent anti-Stokes Raman scattering microscopy for quantitative characterization of mixing and flow in microfluidics," Opt. Lett. 34, 211-213 (2009)

Sort:  Author  |  Year  |  Journal  |  Reset  


  1. A. J. de Mello, Nature 422, 28 (2003). [CrossRef]
  2. S. Leung, R. F. Winkle, R. C. R. Wooton, and A. J. de Mello, Analyst (Cambridge, U.K.) 130, 46 (2005). [CrossRef]
  3. D. E. Hertzog, X. Michalet, M. Jager, X. Kong, J. G. Santiago, S. Weiss, and O. Bakajin, Anal. Chem. 76, 7169 (2004). [CrossRef] [PubMed]
  4. D. Pan, Z. Ganim, J. Kim, M. Verhoeven, J. Lugtenburg, and R. Mathies, J. Am. Chem. Soc. 124, 4857 (2002). [CrossRef] [PubMed]
  5. P. Fletcher, S. Haswell, and X. Zhang, Electrophoresis 24, 3239 (2003). [CrossRef] [PubMed]
  6. T. Araki, K. Ueno, H. Misawa, and N. Kitamura, Anal. Sci. 22, 1283 (2006). [CrossRef] [PubMed]
  7. H. Wang, N. Bao, T. T. Le, C. Lu, and J. Cheng, Opt. Express 16, 5782 (2008). [CrossRef] [PubMed]
  8. G. I. Petrov, R. Arora, A. Saha, R. D. Heathcote, S. Ravula, I. Brener, and V. V. Yakovlev, Proc. SPIE 6442, 644209 (2007). [CrossRef]
  9. D. Schafer, J. A. Squier, J. van Maarseveen, D. Bonn, M. Bonn, and M. Müller, J. Am. Chem. Soc. 130, 11592 (2008). [CrossRef] [PubMed]
  10. D. Sinton, Microfluid. Nanofluid. 1, 2 (2004). [CrossRef]
  11. H. Kinoshita, S. Kaneda, T. Fujii, and M. Oshima, Lab Chip 7, 338 (2007). [CrossRef] [PubMed]
  12. J. M. Chen, T. Horng, and W. Y. Tan, Microfluid. Nanofluid. 2, 455 (2006). [CrossRef]
  13. R. F. Ismagilov, A. D. Stroock, P. J. A. Kenis, G. Whitesides, and H. A. Stone, Appl. Phys. Lett. 76, 2376 (2000). [CrossRef]
  14. D. Schafer, E. A. Gibson, W. Amir, R. Erikson, J. Lawrence, T. Vestad, J. Squier, R. Jimenez, and D. W. M. Marr, Opt. Lett. 32, 2568 (2007). [CrossRef] [PubMed]
  15. T. Park, M. Lee, J. Choo, Y. Kim, E. K. Lee, D. J. Kim, and S. Lee, Appl. Spectrosc. 58, 1172 (2004). [CrossRef] [PubMed]
  16. J. Salmon, A. Ajdari, P. Tabeling, L. Servant, D. Talaga, and M. Joanicot, Appl. Phys. Lett. 86, 094106 (2005). [CrossRef]
  17. S. K. Sia and G. M. Whitesides, Electrophoresis 24, 3563 (2003). [CrossRef] [PubMed]
  18. H. A. Rinia, M. Bonn, and M. Müller, J. Phys. Chem. B 110, 4472-4479 (2006). [CrossRef] [PubMed]
  19. E. M. Vartiainen, H. A. Rinia, M. Müller, and M. Bonn, Opt. Express 14, 3622 (2006). [CrossRef] [PubMed]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


Fig. 1 Fig. 2 Fig. 3

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited