Simultaneous reconstruction of absorption and scattering maps with ultrasound localization: feasibility study using transmission geometry

Minming Huang; Tuqiang Xie; Nan Guang Chen; Quing Zhu

doi:10.1364/AO.42.004102

Applied Optics
Vol. 42,
Issue 19,
pp. 4102-4114
(2003)
•https://doi.org/10.1364/AO.42.004102

Simultaneous reconstruction of absorption and scattering maps with ultrasound localization: feasibility study using transmission geometry

Minming Huang, Tuqiang Xie, Nan Guang Chen, and Quing Zhu

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Minming Huang, Tuqiang Xie, Nan Guang Chen, and Quing Zhu, "Simultaneous reconstruction of absorption and scattering maps with ultrasound localization: feasibility study using transmission geometry," Appl. Opt. 42, 4102-4114 (2003)

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Abstract

We report the experimental results of the simultaneous reconstruction of absorption and scattering coefficient maps with ultrasound localization. Near-infrared (NIR) data were obtained from frequency domain and dc systems with source and detector fibers configured in transmission geometry. High- or low-contrast targets located close to either the boundary or the center of the turbid medium were reconstructed by using NIR data only and NIR data with ultrasound localization. Results show that the mean reconstructed absorption coefficient and the spatial distribution of the absorption map have been improved significantly with ultrasound localization. The improvements in the mean scattering coefficient and the spatial distribution of the scattering coefficient are moderate. When both the absorption and the scattering coefficients are reconstructed the performance of the frequency-domain system is much better than that of the dc system.

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Target Location	Target Contrast	NIR Only		NIR + US		Calibrated Value from Dartmouth College
Target Location	Target Contrast	Mean μ_a (cm^-1)	Mean D (cm)	Mean μ_a (cm^-1)	Mean D (cm)	Mean μ_a (cm^-1)	Mean D (cm)
Close to the boundary	High contrast	0.113 (45.2%a)	0.030 (87%)	0.163 (65.2%a)	0.0355 (102%)	0.2–0.3	0.0347 ± 5%
	Low contrast	0.065 (93%)	0.028 (81%)	0.078 (111%)	0.0355 (102%)	0.07 ± 5%	0.0347 ± 5%
At the center	High contrast	0.081 (32.4%a )	0.0353 (101%)	0.161 (64.4%a )	0.0363 (105%)	0.2–0.3	0.0347 ± 5%
	Low contrast	0.067 (94%)	0.032 (92%)	0.0793 (113%)	0.037 (106%)	0.07 ± 5%	0.0347 ± 5%

Target Location	Target Contrast	NIR Only		NIR + US		Calibrated Value from Dartmouth College
Target Location	Target Contrast	Mean Mua (cm^-1)	Mean D (cm)	Mean Mua (cm^-1)	Mean D (cm)	Mean Mua (cm^-1)	Mean D (cm)
Close to the boundary	High contrast	0.0485 (19.4%a)	0.043 (123%)	0.059 (23.6%a)	0.043 (123%)	0.2–0.3	0.0347 ± 5%
	Low contrast	0.047 (67%)	0.044 (126%)	0.049 (70%)	0.046 (132%)	0.07 ± 5%	0.0347 ± 5%
At the center	High contrast	0.039 (15.6%a )	0.046 (132%)	0.055 (22%a )	0.042 (121%)	0.2–0.3	0.0347 ± 5%
	Low contrast	0.0328 (47%)	0.0486 (140%)	0.051 (73%)	0.044 (126%)	0.07 ± 5%	0.0347 ± 5%

Target Location	Target Contrast	NIR Only		NIR + US		Calibrated Value from Dartmouth College
Target Location	Target Contrast	Mean μ_a (cm^-1)	Mean D (cm)	Mean μ_a (cm^-1)	Mean D (cm)	Mean μ_a (cm^-1)	Mean D (cm)
Close to the boundary	High contrast	0.113 (45.2%a)	0.030 (87%)	0.163 (65.2%a)	0.0355 (102%)	0.2–0.3	0.0347 ± 5%
	Low contrast	0.065 (93%)	0.028 (81%)	0.078 (111%)	0.0355 (102%)	0.07 ± 5%	0.0347 ± 5%
At the center	High contrast	0.081 (32.4%a )	0.0353 (101%)	0.161 (64.4%a )	0.0363 (105%)	0.2–0.3	0.0347 ± 5%
	Low contrast	0.067 (94%)	0.032 (92%)	0.0793 (113%)	0.037 (106%)	0.07 ± 5%	0.0347 ± 5%

Target Location	Target Contrast	NIR Only		NIR + US		Calibrated Value from Dartmouth College
Target Location	Target Contrast	Mean Mua (cm^-1)	Mean D (cm)	Mean Mua (cm^-1)	Mean D (cm)	Mean Mua (cm^-1)	Mean D (cm)
Close to the boundary	High contrast	0.0485 (19.4%a)	0.043 (123%)	0.059 (23.6%a)	0.043 (123%)	0.2–0.3	0.0347 ± 5%
	Low contrast	0.047 (67%)	0.044 (126%)	0.049 (70%)	0.046 (132%)	0.07 ± 5%	0.0347 ± 5%
At the center	High contrast	0.039 (15.6%a )	0.046 (132%)	0.055 (22%a )	0.042 (121%)	0.2–0.3	0.0347 ± 5%
	Low contrast	0.0328 (47%)	0.0486 (140%)	0.051 (73%)	0.044 (126%)	0.07 ± 5%	0.0347 ± 5%

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Applied Optics