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Conferences > BIO > 2002 > MF > MF6

Generalized Adjoint Sensitivities of the Coupled Frequency Domain Fluorescence Diffusion Equations

Francesco Fedele, Jeffrey P. Laible, and Margaret J. Eppstein

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Abstract

The adjoint sensitivity method is applied to the coupled partial differential equations approximating complex fluence in fluorescing system. General equations are derived for Jacobian sensitivity matrices of complex fluence, at both excitation and emission wavelengths, with respect to arbitrary optical parameters. Finite element implementations of these equations are found to be computationally efficient and accurate.

© 2002 Optical Society of America

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