In vivo two photon microscopic study of short term effects of microbeam radiation therapy on the microvasculature in healthy mouse brain

Raphaël Serduc; Régine Farion; Chantal Rémy; Boudewijn van der Sanden; Pascale Vérant; Jean-Claude Vial; Elke Brauer; Alberto Bravin; Jean Laissue; Hans Blattmann

doi:10.1364/ECBO.2005.WF3

Confocal, Multiphoton, and Nonlinear Microscopic Imaging II
Proc. SPIE (Optica Publishing Group, 2005),
paper WF3
•https://doi.org/10.1364/ECBO.2005.WF3

In vivo two photon microscopic study of short term effects of microbeam radiation therapy on the microvasculature in healthy mouse brain

Raphaël Serduc, Régine Farion, Chantal Rémy, Boudewijn van der Sanden, Pascale Vérant, Jean-Claude Vial, Elke Brauer, Alberto Bravin, Jean Laissue, and Hans Blattmann

European Conference on Biomedical Optics 2005

Munich Germany
12–16 June 2005
ISBN: 0-8194-5862-7

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Confocal, Multiphoton and Biomedical Applications (WF)

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R. Serduc, R. Farion, C. Rémy, B. van der Sanden, P. Vérant, J. Vial, E. Brauer, A. Bravin, J. Laissue, and H. Blattmann, "In vivo two photon microscopic study of short term effects of microbeam radiation therapy on the microvasculature in healthy mouse brain," in Confocal, Multiphoton, and Nonlinear Microscopic Imaging II, T. Wilson, ed., Vol. 5860 of Proc. SPIE (Optica Publishing Group, 2005), paper WF3.

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Abstract

The effects of spatial fractionation of high X-Ray doses on mouse brain microvasculature were studied by intravital two-photon microscopy. No breakdown of the blood brain barrier was observed at 312 Gy which would make it an appropriate dose for glioma treatments.

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