OSA's Digital Library

Optics InfoBase > Conference Papers > ECBO > 2007 > CAOII > Page 6627_13 © 2007 OSA

Conference Paper
European Conference on Biomedical Optics
Munich Germany
June 17, 2007
ISBN: 9780819467713

Robust intravascular optical coherence elastography driven by acoustic radiation pressure

Gijs van Soest, Richard R. Bouchard, Frits Mastik, Nico de Jong, and Anton F. W. van der Steen


View Full Text Article

Acrobat PDF (1099 KB) Note that full-text PDFs from conferences typically contain 1-3 pages of content, some or all of which might be an abstract, summary, or miscellaneous items.

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

  • Export Citation/Save Click for help


High strain spots in the vessel wall indicate the presence of vulnerable plaques. The majority of acute cardiovascular events are preceded by rupture of such a plaque in a coronary artery. Intracoronary optical coherence tomography (OCT) can be extended, in principle, to an elastography technique, mapping the strain in the vascular wall. However, the susceptibility of OCT to frame-to-frame decorrelation, caused by tissue and catheter motion, inhibits reliable tissue displacement tracking and has to date obstructed the development of OCT-based intravascular elastography. We introduce a new technique for intravascular optical coherence elastography, which is robust against motion artifacts. Using acoustic radiation force, we apply a pressure to deform the tissue synchronously with the line scan rate of the OCT instrument. Radial tissue displacement can be tracked based on the correlation between adjacent lines, instead of subsequent frames in conventional elastography. The viability of the method is demonstrated with a simulation study. The root mean square (rms) error of the displacement estimate is 0.55 μm, and the rms error of the strain is 0.6%. It is shown that high-strain spots in the vessel wall, such as observed at the sites of vulnerable atherosclerotic lesions, can be detected with the technique. Experiments to realize this new elastographic method are presented. Simultaneous optical and ultrasonic pulse-echo tracking demonstrate that the material can be put in a high-frequency oscillatory motion with an amplitude of several micrometers, more than sufficient for accurate tracking with OCT. The resulting data are used to optimize the acoustic pushing sequence and geometry.

© 2007 SPIE

G. v. Soest, R. R. Bouchard, F. Mastik, N. d. Jong, and A. F. W. v. d. Steen, "Robust intravascular optical coherence elastography driven by acoustic radiation pressure," in Optical Coherence Tomography and Coherence Techniques III, P. Andersen and Z. Chen, eds., Vol. 6627 of Proceedings of SPIE-OSA Biomedical Optics (Optical Society of America, 2007), paper 6627_13.

Sort:  Journal  |  Reset


References are not available for this paper.

OSA is a member of CrossRef.

CrossCheck Deposited