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Conference Paper
European Conference on Biomedical Optics
Munich Germany
June 17, 2007
ISBN: 9780819467737

Algorithms for Muscle Oxygenation Monitoring corrected for Adipose Tissue Thickness

Dmitri Geraskin, Petra Platen, Julia Franke, and Matthias Kohl-Bareis


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The measurement of skeletal muscle oxygenation by NIRS methods is obstructed by the subcutaneous adipose tissue which might vary between < 1 mm to more than 12 mm in thickness. A new algorithm is developed to minimize the large scattering effect of this lipid layer on the calculation of muscle haemoglobin / myoglobin concentrations. First, we demonstrate by comparison with ultrasound imaging that the optical lipid signal peaking at 930 nm is a good predictor of the adipose tissue thickness (ATT). Second, the algorithm is based on measurements of the wavelength dependence of the slope ΔA/Δ of attenuation A with respect to source detector distance ρ and Monte Carlo simulations which estimate the muscle absorption coefficient based on this slope and the additional information of the ATT. Third, we illustrate the influence of the wavelength dependent transport scattering coefficient of the new algorithm by using the solution of the diffusion equation for a two-layered turbid medium. This method is tested on experimental data measured on the vastus lateralis muscle of volunteers during an incremental cycling exercise under normal and hypoxic conditions (corresponding to 0, 2000 and 4000 m altitude). The experimental setup uses broad band detection between 700 and 1000 nm at six source-detector distances. We demonstrate that the description of the experimental data as judged by the residual spectrum is significantly improved and the calculated changes in oxygen saturation are markedly different when the ATT correction is included.

© 2007 SPIE

D. Geraskin, P. Platen, J. Franke, and M. Kohl-Bareis, "Algorithms for Muscle Oxygenation Monitoring corrected for Adipose Tissue Thickness," in Diffuse Optical Imaging of Tissue, R. Cubeddu, ed., Vol. 6629 of Proceedings of SPIE-OSA Biomedical Optics (Optical Society of America, 2007), paper 6629_25.

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