OSA's Digital Library

Optics InfoBase > Conference Papers > ECBO > 2007 > PCS > Page 6632_22 © 2007 OSA

Conference Paper
European Conference on Biomedical Optics
Munich Germany
June 17, 2007
ISBN: 9780819467768
PDT: PRECLINICAL AND CLINICAL STUDIES (PCS)

Design of a light delivery system for the photodynamic treatment of the Crohn's disease

Tanja Gabrecht, Francois Borle, Hubert van den Bergh, Pierre Michetti, Maria-Anna Ortner, and Georges Wagnières

http://dx.doi.org/10.1364/ECBO.2007.6632_22


View Full Text Article

Acrobat PDF (884 KB) Note that full-text PDFs from conferences typically contain 1-3 pages of content, some or all of which might be an abstract, summary, or miscellaneous items.





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations
  • Export Citation/Save Click for help

Abstract

Crohn's disease is an inflammatory bowel disease originating from an overwhelming response of the mucosal immune system. Low dose photodynamic therapy (PDT) may modify the mucosal immune response and thus serve as a therapy for Crohn's disease. Most patients with Crohn's disease show inflammatory reactions in the terminal ileum or colon where PDT treatment is feasible by low-invasive endoscopic techniques. However, the tube like geometry of the colon, it's folding, and the presences of multiple foci of Crohn's lesions along the colon require the development of adequate light delivery techniques. We present a prototype light delivery system for endoscopic clinical PDT in patients with Crohn's disease. The system is based on a cylindrical light diffuser inserted into a diffusing balloon catheter. Homogenous irradiation is performed with a 4 W diode laser at 635 nm. Light dosimetry is performed using a calibrated integrating sphere. The system can be used with conventional colonoscopes and colonovideoscopes having a 3.8 mm diameter working channel. The feasibility of PDT in colon with our prototype was demonstrated in first clinical trials.

© 2007 SPIE

Citation
T. Gabrecht, F. Borle, H. v. d. Bergh, P. Michetti, M. Ortner, and G. Wagnières, "Design of a light delivery system for the photodynamic treatment of the Crohn's disease," in Therapeutic Laser Applications and Laser-Tissue Interactions III, A. Vogel, ed., Vol. 6632 of Proceedings of SPIE-OSA Biomedical Optics (Optical Society of America, 2007), paper 6632_22.
http://www.opticsinfobase.org/abstract.cfm?URI=ECBO-2007-6632_22

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

If you are accessing the full text through a member bundle, please use the Enhanced HTML link to gain access to the citation lists and other restricted features. Note that accessing both the PDF and HTML versions of an article will count as only one download against your account.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

OSA is a member of CrossRef.

CrossCheck Deposited