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Conference Paper
European Conference on Biomedical Optics
Munich Germany
May 22-26, 2011
ISBN: 9780819486844
POSTER SESSION: BIOSPECTROSCOPY AND POC DIAGNOSTICS (PSII)

Surface-enhanced Raman spectroscopy differences of saliva between lung cancer patients and normal people

Xiaozhou Li, Tianyue Yang, Siqi Lib, and Ting Yu

http://dx.doi.org/10.1364/ECBO.2011.808722


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Abstract

Surface enhanced Raman spectroscopy (SERS) has shown the advantage of detecting low concentration biofluids presently. Saliva SERS of 21 lung cancer patients and 22 normal people were measured and differentiated in this paper. Intensities of most peaks of lung cancer patients are weaker than that of normal people, some are stronger but with a small change rate. Those peaks were assigned to proteins and nucleic acids which indicate a corresponding decrease of substance in saliva. Principal component analysis (PCA) and linear discriminant analysis (LDA) were used to deduce and discriminate the two groups of data, resulted in accuracy, sensitivity, and specificity being 84%, 94%, and 81%, respectively. In conclusion, SERS of saliva has the ability of predicting lung cancer.

© 2011 OSA/SPIE

Citation
X. Li, T. Yang, S. Lib, and T. Yu, "Surface-enhanced Raman spectroscopy differences of saliva between lung cancer patients and normal people," in Clinical and Biomedical Spectroscopy and Imaging II, N. Ramanujam and J. Popp, eds., Vol. 8087 of Proceedings of SPIE-OSA Biomedical Optics (Optical Society of America, 2011), paper 808722.
http://www.opticsinfobase.org/abstract.cfm?URI=ECBO-2011-808722


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