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In vivo Brain Imaging with Miniaturized Optical Systems

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Abstract

A longstanding challenge in neuroscience is to understand how populations of individual neurons contribute to animal behavior and brain disease. Addressing this challenge has been difficult partly due to lack of brain imaging technology for use in awake behaving animals. I will describe two approaches to studying the brains of awake behaving mice, one of which also allows time-lapse studies of cells in deep brain areas. Using these methodologies we have studied the dynamics of cerebellar Purkinje cells and hippocampal pyramidal neurons and relationships to rodent behavior.

© 2012 Optical Society of America

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