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Simultaneous dual-band ultra-high resolution optical coherence tomography

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Abstract

Abstract

Ultra-high resolution optical coherence tomography (OCT) imaging is demonstrated simultaneously at 840 nm and 1230 nm central wavelength using an off-the-shelf turn-key supercontinuum light source. Spectral filtering of the light source emission results in a double peak spectrum with average powers exceeding 100 mW and bandwidths exceeding 200 nm for each wavelength band. A free-space OCT setup optimized to support both wavelengths in parallel is introduced. OCT imaging of biological tissue ex vivo and in vivo is demonstrated with axial resolutions measured to be <2 µm and <4 µm at 840 nm and 1230 nm, respectively. This measuring scheme is used to extract spectroscopic features with outstanding spatial resolution enabling enhanced image contrast.

©2007 Optical Society of America

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Figures (5)

Fig. 1.
Fig. 1. Experimental measurements of the unfiltered (black) and filtered (gray) supercontinuum spectra on a linear (a) and a logarithmic (b) scale. Both spectra were normalized to the maximum of the filtered spectra.
Fig. 2.
Fig. 2. Schematic of the prism sequence used for spectral filtering of the light source (a) and of the time-domain free space OCT setup (b) used for simultaneous dual-band UHROCT. M-metallic mirror, SP-short pass filter, T-telescope beam expander and spatial filter, BS-beamsplitter, DC-dispersion compensating glass plates, GM-galvanometer mirror, L-achromatic lens, DM-dichroic mirror, BP-balanced photoreceiver.
Fig. 3.
Fig. 3. Experimental measurements of the spectral bands of the light source used for OCT imaging at 840 nm (a) and 1230 nm (b) central wavelength (gray curves). The black curves correspond to the interference bandwidths calculated by Fourier transform of the linear scaled point spread functions (PSFs) at 830 nm (c) and 1230 nm (d) measured simultaneously by the introduced OCT setup using a single reflection of a glass substrate. The corresponding demodulated logarithmic PSFs are displayed in (e) and (f).
Fig. 4.
Fig. 4. In vivo dual-band UHR-OCT imaging of a human nail fold. (a) and (b) are the intensity based images at 840 nm and 1230 nm, respectively. (c) was derived by frequency compounding and (d) is the differential color image. Image dimensions are 2.5 mm×1.5 mm. S-stratum corneum; E-epidermis; BM-basement membrane; D-dermis; BV-blood vessel; N-nail plate.
Fig. 5.
Fig. 5. Dual-band UHR-OCT imaging of the transitional zone between the stroma and the sclera of a rabbit eye in vitro. (a) was imaged at 840 nm, (b) was imaged at 1230 nm, (c) was derived by frequency compounding and (d) is the differential color image. Image dimensions are 3.5 mm×1.5 mm. Ep-epithelium; St-Stroma; En-endothelium; DM- Descement’s membrane; BV-blood vessels; CA-chamber angle; Ir-iris; Co-conjunctiva; Sc-sclera; CM-ciliary muscle.
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