Abstract

Thermo-optic and reactive mechanisms for label-free sensing of bio-particles are compared theoretically for Whispering Gallery Mode (WGM) resonators (sphere, toroid) formed from silica and stimulated into a first order equatorial mode. Although it has been expected that a thermo-optic mechanism should “greatly enhance” wavelength shift signals [A.M. Armani et al, Science 317, 783-787 (2007)] accompanying protein binding on a silica WGM cavity having high Q (10⁸), for a combination of wavelength (680 nm), drive power (1 mW), and cavity size (43 μm radius), our calculations find no such enhancement. The possible reasons for this disparity are discussed.

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History
Original Manuscript: November 6, 2009
Manuscript Accepted: December 15, 2009
Revised Manuscript: December 14, 2009
Published: December 23, 2009

References

1. F. Vollmer and S. Arnold, “Whispering-gallery-mode biosensing: label-free detection down to single molecules,” Nat. Methods 5(7), 591–596 (2008). [CrossRef]
2. X. Fan, I. M. White, S. I. Shopova, H. Zhu, J. D. Suter, and Y. Sun, “Sensitive optical biosensors for unlabeled targets: a review,” Anal. Chim. Acta 620(1-2), 8–26 (2008). [CrossRef]
3. S. Arnold, M. Khoshsima, I. Teraoka, S. Holler, and F. Vollmer, “Shift of whispering-gallery modes in microspheres by protein adsorption,” Opt. Lett. 28(4), 272–274 (2003). [CrossRef]
4. A. M. Armani, R. P. Kulkarni, S. E. Fraser, R. C. Flagan, and K. J. Vahala, “Label-free, single-molecule detection with optical microcavities,” Science 317(5839), 783–787 (2007). [CrossRef]
5. M. Loncar, “Molecular sensors: Cavities lead the way,” Nat. Photonics 1(10), 565–567 (2007). [CrossRef]
6. D. Evanko, “Incredible shrinking optics,” Nat. Methods 4(9), 683 (2007). [CrossRef]
7. I. Teraoka and S. Arnold, “Theory of resonance shifts in TE and TM whispering gallery modes by nonradial perturbations for sensing applications,” J. Opt. Soc. Am. B 23(7), 1381–1389 (2006). [CrossRef]
8. F. Vollmer, S. Arnold, and D. Keng, “Single virus detection from the reactive shift of a whispering-gallery mode,” Proc. Natl. Acad. Sci. U.S.A. 105(52), 20701–20704 (2008). [CrossRef]
9. S. Arnold, D. Keng, S. I. Shopova, S. Holler, W. Zurawsky, and F. Vollmer, “Whispering Gallery Mode Carousel-a photonic mechanism for enhanced nanoparticle detection in biosensing,” Opt. Express 17(8), 6230–6238 (2009). [CrossRef]
10. J. D. Jackson, Classical Electrodynamics, (3rd ed., John Wiley & Sons Inc., Hoboken, NJ, 1998), pp.154–156.
11. J. V. Beck, K. D. Cole, A. Haji-Sheikh, and B. Litkouhi, Heat conduction using Green’s functions, (Hemisphere Publishing Corp., Washington, DC, 1992).
12. S. Arnold, R. Ramjit, D. Keng, V. Kolchenko, and I. Teraoka, “MicroParticle PhotoPhysics illuminates viral bio-sensing,” Faraday Discuss. 137, 65–83, discussion 99–113 (2007). [CrossRef]
13. S. A. Wise, and R. A. Watters, “Bovine serum albumin (7% Solution) (SRM 927d),” NIST Gaithersburg, MD (2006).
14. W. E. Moerner and D. P. Fromm, “Methods of single-molecule fluorescence spectroscopy and microscopy,” Rev. Sci. Instrum. 74(8), 3597–3619 (2003). [CrossRef]
15. J. B. Jensen, L. H. Pedersen, P. E. Hoiby, L. B. Nielsen, T. P. Hansen, J. R. Folkenberg, J. Riishede, D. Noordegraaf, K. Nielsen, A. Carlsen, and A. Bjarklev, “Photonic crystal fiber based evanescent-wave sensor for detection of biomolecules in aqueous solutions,” Opt. Lett. 29(17), 1974–1976 (2004). [CrossRef]

Author Affiliations

S. Arnold, S. I. Shopova

MicroParticle PhotoPhysics Lab, Polytechnic Institute of NYU, Brooklyn, New York 11201 USA

S. Holler

Novawave Technologies, Redwood Shores, California 94065 USA

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