Abstract

Noninvasive measurements of the scattering coefficients of optically turbid media using angle-resolved optical frequency-domain imaging (OFDI) are demonstrated. It is shown that, by incoherently averaging OFDI reflectance signals acquired at different backscattering angles, speckle noise is reduced, allowing scattering coefficients to be extracted from a single A-line with much higher accuracy than with measurements from conventional OFDI and optical coherence tomography systems. Modeling speckle as a random phasor sum, the relationship between the measurement accuracy and the number of compounded angles is derived. The sensitivity analysis is validated with measurements from a tissue phantom.

© 2007 Optical Society of America

Backscattering spectroscopic contrast with angle-resolved optical coherence tomography

Adrien E. Desjardins, Benjamin J. Vakoc, Guillermo J. Tearney, and Brett E. Bouma
Opt. Lett. 32(21) 3158-3160 (2007)

Tomographic imaging of absolute optical absorption coefficient in turbid media using combined photoacoustic and diffusing light measurements

Lu Yin, Qiang Wang, Qizhi Zhang, and Huabei Jiang
Opt. Lett. 32(17) 2556-2558 (2007)

Speckle reduction in OCT using massively-parallel detection and frequency-domain ranging

A. E. Desjardins, B. J. Vakoc, G. J. Tearney, and B. E. Bouma
Opt. Express 14(11) 4736-4745 (2006)

Angle-resolved Optical Coherence Tomography with sequential angular selectivity for speckle reduction

A. E. Desjardins, B. J. Vakoc, W. Y. Oh, S. M. R. Motaghiannezam, G. J. Tearney, and B. E. Bouma
Opt. Express 15(10) 6200-6209 (2007)

Quantitative characterization of turbid media using pressure contrast acousto-optic imaging

Puxiang Lai, Ronald A. Roy, and Todd W. Murray
Opt. Lett. 34(18) 2850-2852 (2009)