Multimodal optical imaging of microvessel network convective oxygen transport dynamics
Applied Optics, Vol. 48, Issue 10, pp. D187-D197 doi:10.1364/AO.48.00D187
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- OCIS Codes:
- (170.3880) Medical optics and biotechnology : Medical and biological imaging
- (180.0180) Microscopy : Microscopy
- (170.2655) Medical optics and biotechnology : Functional monitoring and imaging
Citation
Casey deDeugd, Mamta Wankhede, and Brian S. Sorg, "Multimodal optical imaging of microvessel network convective oxygen transport dynamics," Appl. Opt. 48, D187-D197 (2009)
http://www.opticsinfobase.org/abstract.cfm?URI=ao-48-10-D187
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Convective oxygen transport by microvessels depends on several parameters, including red blood cell flux and oxygen saturation. We demonstrate the use of intravital microscopy techniques to measure hemoglobin saturations, red blood cell fluxes and velocities, and microvessel cross-sectional areas in regions of microvascular networks containing multiple vessels. With these methods, data can be obtained at high spatial and temporal resolution and correlations between oxygen transport and hemodynamic parameters can be assessed. In vivo data are presented for a mouse mammary adenocarcinoma grown in a dorsal skinfold window chamber model.
© 2009 Optical Society of America
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History
Original Manuscript: September 2, 2008
Manuscript Accepted: January 26, 2009
Revised Manuscript: December 17, 2008
Published: March 2, 2009
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University of Florida
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