We have used Second Harmonic Generation (SHG) imaging microscopy to quantify alterations in the fibrillar collagen assembly in ex vivo human malignant and normal ovarian tissues. We integrate 3-D imaging measurements, bulk optical parameter measurements, and Monte Carlo simulations to isolate the structural factors that are different in these tissues.
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O. Nadiarnykh, R. B. LaComb, M. A. Brewer, and P. J. Campagnola, "Alterations of the ECM During Ovarian Carcinogenesis Studied by Second Harmonic Generation Imaging Microscopy," in Asia Communications and Photonics Conference and Exhibition, Technical Digest (CD) (Optical Society of America, 2009), paper FCC1.
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