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A Novel GRISM-Based Probe for Spectrally Encoded Confocal Microscopy

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Abstract

A device capable of performing endoscopic confocal microscopy could potentially provide physicians with a tool for performing in vivo, non-invasive, subcellular diagnostic imaging. Recently, a novel, sub-micrometer resolution, spectrally encoded confocal microscopy (SECM) imaging system has been presented. It incorporates a quasimonochromatic light source and a diffraction grating to simultaneously detect the reflectivity at multiple points along a transverse line within the sample. Since this method does not require fast spatial scanning within the probe, it is capable of being miniaturized and incorporated into a catheter or endoscope. The work in this abstract demonstrates a novel design for a 10 mm diameter SECM probe, based on a double prism GRISM, which can be used laparoscopically. Furthermore, this design can be scaled without significant modification to less than 5 mm to allow integration with large bore endoscopes.

© 2002 Optical Society of America

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