Abstract
We present noninvasive in vivo measurements of methemoglobin (MetHb) formation and reduction in rabbits using diffuse optical spectroscopy (DOS). The absolute concentrations of MetHb, Hb-R, and Hb-O2 were quantified during nitrite infusions and again during methylene blue treatment. The fractions of MetHb to the total hemoglobin concentration correlate very closely with cooximetry values (R2 > 0.83).
© 2004 Optical Society of America
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