We have developed a novel differential heterodyne Mach-Zehnder interferometer for measuring sub-nanometer displacements in single cells. We describe efforts to measure voltage-dependent refractive index changes and mechanical fluctuations in cultured single neurons.
© 2006 Optical Society of America
(120.0120) Instrumentation, measurement, and metrology : Instrumentation, measurement, and metrology
(120.3180) Instrumentation, measurement, and metrology : Interferometry
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3880) Medical optics and biotechnology : Medical and biological imaging
C. M. Fang-Yen, S. Oh, S. Song, S. Seung, R. R. Dasari, and M. S. Feld, "Differential Heterodyne Mach-Zehnder Interferometer for Measurement of Nanometer-Scale Motions in Living Cells," in Biomedical Optics, Technical Digest (CD) (Optical Society of America, 2006), paper MD9.