Abstract
3D optoacoustic tomography system was developed combining advantages of pulsed optical spectroscopy and high-resolution ultrasonic detection, characterized and shown to produce high-contrast 3D maps of optical absorbance through the whole body of an animal with resolution better than 0.5 mm. Much smaller tissue structures and microvessels can be visualized in case of sufficient contrast. An ultrawide-band of ultrasonic frequencies present in optoacoustic signals contains wealth of information, which can be revealed through proper filtering and post-processing. We demonstrated that either larger anatomy, such as organs or major vessels, or the smaller structures (kidney medullas, ovarian arteries) and even microvasculature can be visualized depending on methods of signal and image processing. Figures a and b below shows exemplary images of mouse anatomy and vasculature.
© 2010 Optical Society of America
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