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A rapid line-scan ophthalmoscope for intrinsic optical signal imaging of retinal photoreceptors

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Abstract

The purpose of this study was to validate intrinsic optical signal (IOS) mapping of localized retinal dysfunctions. A rapid line-scan confocal ophthalmoscope was constructed to achieve in vivo IOS imaging at cellular and millisecond resolution. A dynamic spatiotemporal filtering was developed to reject signal contamination of hemodynamic changes on fast IOS recording. Comparative IOS and electroretinography (ERG) recordings revealed a close correlation between the confocal-IOS and retinal ERG, particularly the ERG a-wave. IOS identification of localized (30 µm) retinal dysfunction was validated using laser-injured frog eyes.

© 2013 Optical Society of America

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