Light-scattering spectroscopy on single gold nanoparticles is used to detect molecular binding events. We show that our method is able to detect less than 200 molecular binding events under physiological condidtions.
© 2004 Optical Society of America
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(290.0290) Scattering : Scattering
(290.5850) Scattering : Scattering, particles
G. Raschke, S. Kowarik, T. Franzl, C. Sönnichsen, T. A. Klar, J. Feldmann, A. Nichtl, and K. Kürzinger, "Biomolecular sensor based on optical spectroscopy of single gold nanoparticles," in Conference on Lasers and Electro-Optics/International Quantum Electronics Conference and Photonic Applications Systems Technologies, Technical Digest (CD) (Optical Society of America, 2004), paper CThI2.
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