We directly observe three-dimensional motion of a gold nanoparticle on the membrane of a living cell by using non-interferometric widefield optical profilometry. We identify the occurrence of particle internalization and actin aggregation which indicates endocytosis.
© 2008 Optical Society of America
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.1530) Medical optics and biotechnology : Cell analysis
(170.3880) Medical optics and biotechnology : Medical and biological imaging
C. Lee, C. Wang, C. Lee, C. Huang, J. Lin, and P. Wei, "Three-Dimensional Motion of a Nanoparticle on the Cell Membrane Observed by Non-Interferometric Widefield Optical Profilometry," in Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science Conference and Photonic Applications Systems Technologies, OSA Technical Digest (CD) (Optical Society of America, 2008), paper CWM4.
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