A one-dimensional photonic crystal structure in a total-internal-reflection geometry has been developed for real-time, label-free specific protein binding detection. With the streptavidin-biotin system, an ultra low mass density detection limit 24 fg/mm<sup>2</sup>was achieved.
© 2009 The Optical Society
(230.0230) Optical devices : Optical devices
(280.0280) Remote sensing and sensors : Remote sensing and sensors
(280.1415) Remote sensing and sensors : Biological sensing and sensors
(230.5298) Optical devices : Photonic crystals
Y. Guo, T. P. Thomas, J. Y. Ye, A. Myc, J. R. Baker Jr., and T. B. Norris, "Real-Time, Label-Free Protein Binding Detection with a One Dimensional Photonic Crystal Sensor," in Conference on Lasers and Electro-Optics/International Quantum Electronics Conference, OSA Technical Digest (CD) (Optical Society of America, 2009), paper CTuCC6.