Amplification-free nucleic acid testing using molecular beacon detection on an optofluidic chip is reported. A limit of detection at the single molecule detection level (10pM) and excellent specificity (single nucleotide mismatches) is observed.
© 2012 OSA
(130.3120) Integrated optics : Integrated optics devices
(280.1415) Remote sensing and sensors : Biological sensing and sensors
(280.4788) Remote sensing and sensors : Optical sensing and sensors
P. Measor, Y. Zhao, A. Hawkins, and H. Schmidt, "An Ultrasensitive Optofluidic Nucleic Acid Biosensor," in Conference on Lasers and Electro-Optics 2012, OSA Technical Digest (online) (Optical Society of America, 2012), paper CW1G.6.