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Conferences > CLEO_SI > 2013 > CTh3I > CTh3I.1

High-throughput screening of blood samples based on structured illumination on-chip imaging

Serap Altay Arpali, Caglar Arpali, Ahmet F. Coskun, Hsin-Hao Chiang, and Aydogan Ozcan

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Abstract

We demonstrate a high-throughput fluorescent on-chip imaging platform, using structured illumination that can rapidly screen large volumes of scattering media such as undiluted whole blood samples (e.g., ~ 0.3-0.7 mL) for detection of fluorescent micro-objects at low concentrations H J fl Ȉ -100 particles/mL). This imaging modality might especially be useful for rare cell applications involving whole blood samples, such as detection of circulating tumor cells.

© 2013 Optical Society of America

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