The effects of spatial fractionation of high X-Ray doses on mouse brain microvasculature were studied by two-photon microscopy. No breakdown of the BBB was observed at 312Gy which would make it appropriate for glioma treatments.
© 2005 Optical Society of America
(100.0100) Image processing : Image processing
(100.2960) Image processing : Image analysis
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.6900) Medical optics and biotechnology : Three-dimensional microscopy
P. Verant, R. Serduc, R. Farion, C. Remy, B. Van Der Sanden, J. Vial, E. Brauer, A. Bravin, J. Laissue, and H. Blattman, "In vivo Two Photon Microscopic Study of Short Term Effects of Microbeam Radiation Therapy on the Micorvasculature in Healthy Mouse Brain," in Confocal, Multiphoton, and Nonlinear Microscopic Imaging II, T. Wilson, ed., Vol. 5860 of Proc. SPIE (Optical Society of America, 2005), paper WF3.