We have demonstrated that in vitro fluorescence spectroscopic analysis of diseased carotid arteries can identify clinically relevant compositional changes in connective tissue (collagen type I, III, IV and elastin) associated with plaque remodeling and instability.
© 2005 Optical Society of America
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.1610) Medical optics and biotechnology : Clinical applications
(300.0300) Spectroscopy : Spectroscopy
(300.2530) Spectroscopy : Fluorescence, laser-induced
R. M. Korol, P. B. Canham, H. M. Finlay, R. R. Hammond, M. Quantz, G. G. Ferguson, and A. R. Lucas, "Optical Detection of Structural Changes in Atherosclerotic Plaque," in Diagnostic Optical Spectroscopy in Biomedicine III, A. Mycek, ed., Vol. 5862 of Proc. SPIE (Optical Society of America, 2005), paper WI5.
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