Spectral differences of surface enhanced Raman scattering (SERS) were observed for human insulin versus analog and for phosphorylated protein versus unphosphorylated. Adaptive silver films enable soft protein deposition and improved SERS enhancement. This allows to detect small structural differences of proteins at sub-monolayer density.
© 2004 Optical Society of America
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(300.6330) Spectroscopy : Spectroscopy, inelastic scattering including Raman
(300.6450) Spectroscopy : Spectroscopy, Raman
E. N. Khaliullin, V. Drachev, M. Thoreson, V. Jo Davisson, M. Narsimhan, D. Ben-Amotz, and V. M. Shalaev, "Protein sensing with SERS: Insulin variants and phosphorylation detection," in Frontiers in Optics 2004/Laser Science XXII/Diffractive Optics and Micro-Optics/Optical Fabrication and Testing, OSA Technical Digest Series (Optical Society of America, 2004), paper FTuE2.
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