Instrumentation is developed for real-time determination of photodynamic therapy dosimetry in vivo, employing measurements of fluorescence emission spectra corrected for effects of dynamic tissue optical properties using white light diffuse reflectance. This system accurately measures photosensitizer photobleaching, photoproduct formation, and tissue oxygenation, all of which are useful as dose metrics.
© 2004 Optical Society of America
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(170.1870) Medical optics and biotechnology : Dermatology
(170.5180) Medical optics and biotechnology : Photodynamic therapy
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence
W. J. Cottrell, T. H. Foster, and A. R. Oseroff, "Photodynamic therapy dosimetry by fluorescence and reflectance spectroscopies," in Frontiers in Optics 2004/Laser Science XXII/Diffractive Optics and Micro-Optics/Optical Fabrication and Testing, OSA Technical Digest Series (Optical Society of America, 2004), paper FTuG49.
References are not available for this paper.