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Optica Publishing Group
  • Frontiers in Optics 2004/Laser Science XXII/Diffractive Optics and Micro-Optics/Optical Fabrication and Testing
  • OSA Technical Digest Series (Optica Publishing Group, 2004),
  • paper FTuG49
  • https://doi.org/10.1364/FIO.2004.FTuG49

Photodynamic therapy dosimetry by fluorescence and reflectance spectroscopies

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Abstract

Instrumentation is developed for real-time determination of photodynamic therapy dosimetry in vivo, employing measurements of fluorescence emission spectra corrected for effects of dynamic tissue optical properties using white light diffuse reflectance. This system accurately measures photosensitizer photobleaching, photoproduct formation, and tissue oxygenation, all of which are useful as dose metrics.

© 2004 Optical Society of America

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