SNARF-1, a pH-sensitive fluorescent probe, was used to perform fluorescence ratio imaging in tumor and surrounding tissue. A pH resolution of 0.042 pH units was achieved. pH gradients extending into the peritumoral region were observed.
© 2005 Optical Society of America
B. M. Kaylor, R. A. Gatenby, and A. F. Gmitro, "In Vivo Measurement of pH in Tumor and Surrounding Tissue Using Fluorescence Ratio Imaging," in Frontiers in Optics, OSA Technical Digest Series (Optical Society of America, 2005), paper FMI1.
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