Using novel femtosecond laser pulse shaping techniques and a virtually background-free detection strategy we demonstrate strong self-phase modulation signatures of neuronal activity in hippocampal brain slices without the use of exogenous contrast agents.
© 2008 The Optical Society
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.7160) Medical optics and biotechnology : Ultrafast technology
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging
H. C. Liu, M. C. Fischer, P. Samineni, Y. Escobedo-Lozoya, R. Yasuda, and W. S. Warren, "Intrinsic Nonlinear Optical Signatures of Neuronal Activity," in Frontiers in Optics 2008/Laser Science XXIV/Plasmonics and Metamaterials/Optical Fabrication and Testing, OSA Technical Digest (CD) (Optical Society of America, 2008), paper FWD2.
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