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Monitoring Cocrystal Formation of Binary Mixture of Piracetam and 2,5-dihydroxybenzoic Acid Compounds by Terahertz Spectroscopical Technique

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Abstract

Far-infrared vibrational absorption of cocrystal formation between 2,5-dihydroxybenzoic acid and piracetam compounds under solvent evaporation and grinding methods have been investigated using terahertz time-domain spectroscopy. The experimental results show large difference among absorption spectra of the formed cocrystals and the involved starting parent molecules. With grinding method, the reaction process can be monitored directly using THz-TDS technique. The results indicate that THz-TDS technology can not only give a new experimental method to identify and characterize the cocrystal formation in molecule-level, but also provide a useful and promising tool for further monitoring the reaction dynamic involving two or more molecular crystals in pharmaceutical industry.

© 2012 Optical Society of America

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