Abstract
Research world-wide on biosensing techniques is motivated by numerous applications in clinical diagnostics, genetic screenings, proteomics, and single-molecule detection, for example. However, the important problem of detecting in parallel a large number of molecular species from very small samples remains an elusive goal. This work represents a step in that direction through the development of a biosensor array platform in which enhanced fluorescence transduction occurs through the optical excitation of molecules located within metallic nanocavities. These nanocavities are 100-200nm in diameter and are arranged in periodic or random two-dimensional arrays, which are fabricated in 70nm-thick gold films by e-beam lithography using negative e-beam resist.
© 2005 Optical Society of America
PDF ArticleMore Like This
Y. Liu and S. Blair
PD5 Integrated Photonics Research (IPR) 2003
Sudeshna Pal, Elisa Guillermain, Benjamin L. Miller, and Philippe M. Fauchet
FWF1 Frontiers in Optics (FiO) 2010
Jiří Homola
CH5_3 The European Conference on Lasers and Electro-Optics (CLEO/Europe) 2009