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Biosensing based upon molecular confinement in metallic nanocavity arrays

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Abstract

Research world-wide on biosensing techniques is motivated by numerous applications in clinical diagnostics, genetic screenings, proteomics, and single-molecule detection, for example. However, the important problem of detecting in parallel a large number of molecular species from very small samples remains an elusive goal. This work represents a step in that direction through the development of a biosensor array platform in which enhanced fluorescence transduction occurs through the optical excitation of molecules located within metallic nanocavities. These nanocavities are 100-200nm in diameter and are arranged in periodic or random two-dimensional arrays, which are fabricated in 70nm-thick gold films by e-beam lithography using negative e-beam resist.

© 2005 Optical Society of America

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