Novel Lysosomal Targeting Two-Photon Fluorescence Probe Based on Fluorene Difluoroboron β-diketonate

Andrew Frazer; Alma R. Morales; Adam Woodward; Simon Tang; Kevin D. Belfield; Kevin D. Belfield

doi:10.1364/OMP.2013.MTh1C.3

Optics in the Life Sciences
OSA Technical Digest (online) (Optica Publishing Group, 2013),
paper MTh1C.3
•https://doi.org/10.1364/OMP.2013.MTh1C.3

Novel Lysosomal Targeting Two-Photon Fluorescence Probe Based on Fluorene Difluoroboron β-diketonate

Andrew Frazer, Alma R. Morales, Adam Woodward, Simon Tang, and Kevin D. Belfield

Optical Molecular Probes, Imaging and Drug Delivery 2013

Waikoloa Beach, Hawaii United States
14–18 April 2013
ISBN: 978-1-55752-966-4

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Imaging Cell Function (MTh1C)

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A. Frazer, A. R. Morales, A. Woodward, S. Tang, and K. D. Belfield, "Novel Lysosomal Targeting Two-Photon Fluorescence Probe Based on Fluorene Difluoroboron β-diketonate," in Optics in the Life Sciences, OSA Technical Digest (online) (Optica Publishing Group, 2013), paper MTh1C.3.

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Abstract

We report the synthesis and photophysical characteristics of a two photon fluorescent (2PF) fluorene-based pyridyl difluoroboron-β-diketonate, which when incubated in HCT 116 cells shows superior accumulation in lysosomes in both isolate and encapsulated pluronics.

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