This paper describes holographic optical coherence imaging of cellular motility in living, diseased and pharmacologically treated tissue. The coherence gate is a photorefractive quantum well device that facilitates the elimination of multiply scattered light from the tissue. To accomplish high-fidelity functional imaging of metabolic activity at depth within the tissue, spatial coherence in the illuminating beam must be controlled to reduce channel cross-talk. We show results for rat osteogenic sarcoma tumor spheroids.
© 2005 Optical Society of America
(030.6140) Coherence and statistical optics : Speckle
(070.2580) Fourier optics and signal processing : Paraxial wave optics
(090.0090) Holography : Holography
(170.1650) Medical optics and biotechnology : Coherence imaging
(190.5970) Nonlinear optics : Semiconductor nonlinear optics including MQW
K. Jeong, J. J. Turek, and D. D. Nolte, "Biomedical Functional Imaging of Tissue in Coherence-Domain Speckle Holography," in Photorefractive Effects, Materials, and Devices, G. Zhang, D. Kip, D. Nolte, and J. Xu, eds., Vol. 99 of OSA Trends in Optics and Photonics (Optical Society of America, 2005), paper 796.
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