Abstract

A low density lipoprotein (LDL) cholesterol testing device, structured with serial reflected face-to-face mirror (SRM) allowing spectrophotometry measurements, is presented. The spectrophotometry has been employed to measure the amount of light that a sample absorbs, but it generally should have had path length longer than 10 mm to secure enough sensitivity. Such requirement of path length has often been problematic in implementing a thin type of lab on a disc (LOD). We developed the SRM system which was implemented in a detection chamber with 1.4mm thickness, providing path length longer than 10mm, and thus straightforwardly being applicable to LOD as thin as a compact disc. The experimental results show that the SRM system gives not only a much thinner design compared to the conventional spectrophotometry-based LOD but also a comparable performance to already commercialized spectrometers.

© 2013 Optical Society of Korea

LSPR-based cholesterol biosensor using a tapered optical fiber structure

Santosh Kumar, Brajesh Kumar Kaushik, Ragini Singh, Nan-Kuang Chen, Qing Shan Yang, Xia Zhang, Wenjun Wang, and Bingyuan Zhang
Biomed. Opt. Express 10(5) 2150-2160 (2019)

Fraction estimation of small, dense LDL using autocorrelation function of dynamic light scattering

Suchin Trirongjitmoah, Toshihiro Sakurai, Kazuya Iinaga, Hitoshi Chiba, and Koichi Shimizu
Opt. Express 18(6) 6315-6326 (2010)

Novel fluorescent probe for low density lipoprotein, based on the enhancement of Europium emission band

L. C. Courrol, A.M. Monteiro, F.R.O. Silva, L. Gomes, N.D. Vieira, M.A. Gidlund, and A.M. Figueiredo Neto
Opt. Express 15(11) 7066-7074 (2007)

Sub-Doppler spectroscopy using a multiple-reflection mirror system

Yit-Tsong Chen, Joan M. Frye, and Takeshi Oka
J. Opt. Soc. Am. B 3(7) 935-939 (1986)

Fabrication of a compact reflective long-period grating sensor with a cladding-mode-selective fiber end-face mirror

Meng Jiang, A. Ping Zhang, Yang-Chun Wang, Hwa-Yaw Tam, and Sailing He
Opt. Express 17(20) 17976-17982 (2009)