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System for the optical diagnosis of tumors, and using it to identify pituitary adenoma

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Abstract

This paper discusses the autofluorescence kinetics of healthy and tumorous tissues of the pituitary, as well as their diffuse scattering spectra in the wavelength ranges, respectively, of 380–600 and 350–1000 nm. Measurements were made by means of apparatus consisting of two units, a time-correlated photon-counting system, and a unit for exciting and recording the spectra of diffusely scattered light. It is found that a significant difference is observed in the mean autofluorescence time of tumorous and healthy tissues in the 380–600-nm spectral range. It is established that the intensity of diffusely reflected light is significantly lower in samples of healthy tissues than in samples of pituitary adenoma in the wavelength range 650–1000 nm. The sensitivity and specificity of the identification of the pituitary tissues after the data were processed by means of discriminant analysis were 100%.

© 2014 Optical Society of America

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