Maximum-likelihood criterion and single-molecule detection
Applied Optics, Vol. 34, Issue 3, pp. 514-526 (1995)
http://dx.doi.org/10.1364/AO.34.000514
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Abstract
The maximum-likelihood criterion is shown to be a powerful method for analyzing fluorescence-detection data with small signal-to-noise ratios. A probability study of the maximum-likelihood criterion for a supposed single-molecule detection experiment is presented that takes into account the photokinetics of the molecule to be detected, its diffusion, and the laser-beam geometry. Furthermore, the efficiency of time-integrated and time-correlated single-photon counting methods are studied and compared.
© 1995 Optical Society of America
Citation
Jörg Enderlein, "Maximum-likelihood criterion and single-molecule detection," Appl. Opt. 34, 514-526 (1995)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-34-3-514
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