OSA's Digital Library

Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Vol. 37, Iss. 13 — May. 1, 1998
  • pp: 2640–2645

Quantitative analysis of metabolic gases by multichannel raman spectroscopy: use of a newly designed elliptic–spherical integration type of cell holder

H. Yamamoto, H. Uenoyama, K. Hirai, X. Dou, and Y. Ozaki  »View Author Affiliations


Applied Optics, Vol. 37, Issue 13, pp. 2640-2645 (1998)
http://dx.doi.org/10.1364/AO.37.002640


View Full Text Article

Enhanced HTML    Acrobat PDF (175 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

We describe the quantitative analysis of some metabolic gases by multichannel Raman spectroscopy. Raman spectra were measured for air, acetone, ammonia, carbon dioxide, and mixed gas consisting of acetone, ammonia, and air. We designed a new elliptic–spherical integration type of cell holder to obtain the Raman spectra of gases with a high signal-to-noise ratio. Concentrations of acetone, ammonia, and carbon dioxide were determined by the peak intensities of Raman bands at 2940, 3228, and 1385 cm-1, respectively. To compensate for the fluctuations of Raman intensities caused by several factors, such as the fluctuations of laser power, the peak intensity of a band at 2324 cm-1 due to nitrogen gas was used as an internal intensity standard. The correlation coefficient between the corrected Raman intensity at 2940 cm-1 and the concentration of acetone was calculated to be 0.984 for a concentration range of 2–12 ppm. The detection limit of acetone gas was found to be 2 ppm.

© 1998 Optical Society of America

OCIS Codes
(300.6170) Spectroscopy : Spectra
(300.6450) Spectroscopy : Spectroscopy, Raman

History
Original Manuscript: August 7, 1997
Revised Manuscript: December 9, 1997
Published: May 1, 1998

Citation
H. Yamamoto, H. Uenoyama, K. Hirai, X. Dou, and Y. Ozaki, "Quantitative analysis of metabolic gases by multichannel raman spectroscopy: use of a newly designed elliptic–spherical integration type of cell holder," Appl. Opt. 37, 2640-2645 (1998)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-37-13-2640


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. A. Manolis, “The diagnostic potential of breath analysis,” Clin. Chem. 29, 5–15 (1983). [PubMed]
  2. J. A. Perman, “Clinical application of breath hydrogen measurements,” Can. J. Physiol. Pharmacol. 69, 111–115 (1991). [CrossRef] [PubMed]
  3. M. Phillips, J. Greenberg, “Ion-trap detection of volatile organic compounds in alveolar breath,” Clin. Chem. 38, 60–65 (1992). [PubMed]
  4. H. Yamamoto, H. Uenoyama, H. Ueda, M. Hiromoto, K. Shii, J. Hari, T. Hozumi, Y. Ishida, T. Kazumi, Y. Hara, M. Kurusu, J. Kato, K. Narutaki, S. Baba, R. J. Kolaja, “A breath ketone determination method as a noninvasive test for the metabolic indicator in diabetes and obesity,” in Diabetes 1994, S. Baba, T. Kaneko, eds. (Elsevier Science, Amsterdam, 1995), pp. 617–621.
  5. H. Ueda, M. Hiromoto, H. Uenoyama, H. Yamamoto, K. Shii, S. Baba, R. J. Kolaja, “Development of a breath ketone analyser for clinical practice,” in Diabetes 1994, S. Baba, T. Kaneko, eds. (Elsevier, Amsterdam, 1995), pp. 1138–1142.
  6. A. J. Berger, Y. Wang, D. M. Sammeth, I. Itzkan, K. Kneipp, M. S. Feld, “Aqueous dissolved gas measurements using near-infrared Raman spectroscopy,” Appl. Spectrosc. 49, 1164–1169 (1995). [CrossRef]
  7. R. A. VanWagenen, D. R. Westenskow, R. E. Benner, D. E. Gregosis, D. L. Coleman, “Dedicated monitoring of anesthetic and respiratory gases by Raman scattering,” J. Clin. Monitor. 2, 215–222 (1986). [CrossRef]
  8. W. F. Murphy, “Chemical applications of gas-phase Raman spectroscopy,” in Analytical Raman Spectroscopy (Wiley Interscience, New York, 1991), pp. 425–451.
  9. X. Dou, Y. Yamaguchi, H. Yamamoto, H. Uenoyama, Y. Ozaki, “Biological applications of anti-Stokes Raman spectroscopy: quantitative analysis of glucose in plasma and serum by a highly sensitive multichannel Raman spectrometer,” Appl. Spectrosc. 50, 1301–1306 (1996). [CrossRef]
  10. X. Dou, Y. Yamaguchi, H. Yamamoto, S. Doi, Y. Ozaki, “Quantitative analysis of metabolites in urine by anti-Stokes Raman spectroscopy,” Biospectroscopy 3, 113–120 (1997). [CrossRef]
  11. X. Dou, T. Takama, Y. Yamaguchi, H. Yamamoto, Y. Ozaki, “Novel enzyme-immunoassay utilizing surface-enhanced Raman scattering of enzyme reaction product,” Anal. Chem. 69, 1492–1495 (1997). [CrossRef]
  12. X. Dou, T. Takama, Y. Yamaguchi, H. Yamamoto, Y. Ozaki, “A highly sensitive, compact Raman system without a spectrometer for quantitative analysis of biological samples,” Vib. Spectrosc. 14, 199–205 (1997). [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited