An amplitude-sensitive optical heterodyne polarimeter was set up to monitor noninvasively the aqueous glucose concentration in a rabbit’s eye. A Zeeman laser in conjunction with a Glan–Thompson analyzer was used to generate an optical heterodyne signal. The amplitude of the heterodyne signal linearly related to the optical rotation angle of the aqueous glucose. The concentration of the aqueous glucose in a rabbit’s eyeball was measured <i>in vivo</i>. There was a 30-min time delay between observations of aqueous glucose and blood glucose. The detection capability and the reproducibility of the experiment are demonstrated and discussed.
© 1998 Optical Society of America
(040.2840) Detectors : Heterodyne
(120.2130) Instrumentation, measurement, and metrology : Ellipsometry and polarimetry
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(260.5430) Physical optics : Polarization
Chien Chou, Chien-Yuan Han, Wen-Chuan Kuo, Yeu-Chuen Huang, Ching-Mei Feng, and Jenn-Chyang Shyu, "Noninvasive Glucose Monitoring in Vivo with an Optical Heterodyne Polarimeter," Appl. Opt. 37, 3553-3557 (1998)