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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Vol. 38, Iss. 25 — Sep. 1, 1999
  • pp: 5480–5490

Spectroscopic diffuse optical tomography for the quantitative assessment of hemoglobin concentration and oxygen saturation in breast tissue

Troy O. McBride, Brian W. Pogue, Ellen D. Gerety, Steven B. Poplack, Ulf L. Österberg, and Keith D. Paulsen  »View Author Affiliations


Applied Optics, Vol. 38, Issue 25, pp. 5480-5490 (1999)
http://dx.doi.org/10.1364/AO.38.005480


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Abstract

Near-infrared (NIR) spectroscopic diffuse tomography has been used to map the hemoglobin concentration and the hemoglobin oxygen saturation quantitatively in tissuelike phantoms and to determine average values in vivo. A series of phantom calibrations were performed to achieve quantitatively accurate images of the absorption and the reduced scattering coefficients at multiple optical wavelengths. A least-squares fit was applied to absorption-coefficient images at multiple NIR wavelengths to obtain hemoglobin images of the concentration and the hemoglobin oxygen saturation. Objects of varying hemoglobin concentration and oxygen saturation within highly scattering media were localized and imaged to within 15% of their actual values. The average hemoglobin concentration and oxygen saturation of breast tissue was measured in vivo for two women volunteers. The potential application for the diagnosis of breast tumors is discussed.

© 1999 Optical Society of America

OCIS Codes
(110.3080) Imaging systems : Infrared imaging
(170.3830) Medical optics and biotechnology : Mammography
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5270) Medical optics and biotechnology : Photon density waves
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(170.6960) Medical optics and biotechnology : Tomography

History
Original Manuscript: December 8, 1998
Revised Manuscript: May 25, 1999
Published: September 1, 1999

Citation
Troy O. McBride, Brian W. Pogue, Ellen D. Gerety, Steven B. Poplack, Ulf L. Österberg, and Keith D. Paulsen, "Spectroscopic diffuse optical tomography for the quantitative assessment of hemoglobin concentration and oxygen saturation in breast tissue," Appl. Opt. 38, 5480-5490 (1999)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-38-25-5480

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