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Applied Optics

Applied Optics


  • Vol. 39, Iss. 34 — Dec. 1, 2000
  • pp: 6396–6405

Interferometric sensor for detection of surface-bound bioreactions

Albrecht Brandenburg, Ralf Krauter, Christa Künzel, Monika Stefan, and Heinrich Schulte  »View Author Affiliations

Applied Optics, Vol. 39, Issue 34, pp. 6396-6405 (2000)

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An integrated optical interferometer for direct detection of affinity reactions is presented. A modern version of a Young’s interferometer is built with a waveguide structure as beam splitter and as sensing element. Resistive waveguides were produced by plasma-enhanced chemical vapor deposition of silicon oxinitride. At the output of this device a fringe pattern is detected by a CCD line camera. The adsorption of molecules on top of the waveguides is observed with a detection limit of 750 fg/mm2. The resolvable variation of effective refractive index is 9 × 10-8.

© 2000 Optical Society of America

OCIS Codes
(130.6010) Integrated optics : Sensors
(130.6750) Integrated optics : Systems
(230.3120) Optical devices : Integrated optics devices
(230.7380) Optical devices : Waveguides, channeled

Original Manuscript: August 7, 2000
Revised Manuscript: August 7, 2000
Published: December 1, 2000

Albrecht Brandenburg, Ralf Krauter, Christa Künzel, Monika Stefan, and Heinrich Schulte, "Interferometric sensor for detection of surface-bound bioreactions," Appl. Opt. 39, 6396-6405 (2000)

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