OSA's Digital Library

Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Vol. 40, Iss. 10 — Apr. 1, 2001
  • pp: 1742–1746

Unified Analysis of the Sensitivities of Reflectance and Path Length to Scattering Variations in a Diffusive Medium

Hanli Liu  »View Author Affiliations


Applied Optics, Vol. 40, Issue 10, pp. 1742-1746 (2001)
http://dx.doi.org/10.1364/AO.40.001742


View Full Text Article

Acrobat PDF (106 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

A unified analysis is presented for the sensitivities of reflectance and path length to scattering variations in a diffusive medium, using an improved solution of the steady-state diffusion equation. This approach enables one to (1) explain theoretically two kinds of dependency of near-infrared reflectance on source–detector separations and (2) obtain an analytical expression for optical path lengths. The results shown here are consistent with those of Kumar and Schmitt [Appl. Opt. <b>36,</b> 2286 (1997)] and Mourant <i>et al</i>. [Appl. Opt. <b>36,</b> 5655 (1997)]. Also, discussions are given on (1) possible reasons for some inconsistency between the conclusion drawn by Mourant <i>et al.</i> and results given here and (2) the usefulness of making reflectance measurements while minimizing the sensitivity of reflectance and path length to scattering variations.

© 2001 Optical Society of America

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.5280) Medical optics and biotechnology : Photon migration
(290.1350) Scattering : Backscattering
(290.1990) Scattering : Diffusion
(290.4210) Scattering : Multiple scattering
(290.7050) Scattering : Turbid media

Citation
Hanli Liu, "Unified Analysis of the Sensitivities of Reflectance and Path Length to Scattering Variations in a Diffusive Medium," Appl. Opt. 40, 1742-1746 (2001)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-40-10-1742


Sort:  Author  |  Year  |  Journal  |  Reset

References

  1. G. Kumar and J. M. Schmitt, “Optimal probe geometry for near-infrared spectroscopy of biological tissue,” Appl. Opt. 36, 2286–2293 (1997).
  2. J. R. Mourant, I. J. Bigio, D. A. Jack, T. M. Johnson, and H. D. Miller, “Measuring absorption coefficients in small volumes of highly scattering media: source–detector separations for which path lengths do not depend on scattering properties,” Appl. Opt. 36, 5655–5661 (1997).
  3. A. Kienle and M. S. Patterson, “Improved solutions of the steady-state and the time-resolved diffusion equations for reflectance from a semi-infinite turbid medium,” J. Opt. Soc. Am. A 14, 246–254 (1997).
  4. T. J. Farrell and M. S. Patterson, “A diffusion theory model of spatially resolved, steady-state diffuse reflectance for the noninvasive determination of tissue optical properties in vivo,” Med. Phys. 19, 879–888 (1992).
  5. H. Liu, B. Beauvoit, M. Kimura, and B. Chance, “Dependence of tissue optical properties on solute-induced changes in refractive index and osmolarity,” J. Biomed. Opt. 1, 200–211 (1996).
  6. E. M. Sevick, B. Chance, J. Leigh, S. Nioka, and M. Maris, “Quantitation of time- and frequency-resolved optical spectra for the determination of tissue oxygenation,” Anal. Biochem. 195, 330–351 (1991).
  7. W. M. Star, “Diffusion theory of light transport,” in Optical-Thermal Response of Laser-Irradiated Tissue, A. J. Welch and M. J. C. Van Gemert, eds. (Plenum, New York, 1995).
  8. H. Liu, Y. Song, K. L. Worden, X. Jiang, A. Constantinescu, and R. P. Mason, “Noninvasive investigation of blood oxygenation dynamics of tumors by near-infrared spectroscopy,” Appl. Opt. 39, 5231–5243 (2000).
  9. J. R. Mourant, T. M. Johnson, G. Los, and I. J. Bigio, “Non-invasive measurement of chemotherapy drug concentrations in tissue: preliminary demonstrations of in vivo measurements,” Phys. Med. Biol. 44, 1397–1417 (1999).

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


« Previous Article

OSA is a member of CrossRef.

CrossCheck Deposited