OSA's Digital Library

Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Vol. 40, Iss. 22 — Aug. 1, 2001
  • pp: 3792–3799

Particle size analysis of turbid media with a single optical fiber in contact with the medium to deliver and detect white light

Murat Canpolat and Judith R. Mourant  »View Author Affiliations


Applied Optics, Vol. 40, Issue 22, pp. 3792-3799 (2001)
http://dx.doi.org/10.1364/AO.40.003792


View Full Text Article

Enhanced HTML    Acrobat PDF (358 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

Wavelength-dependent elastic-scattering spectra of highly scattering media measured with only a single fiber for both light delivery and collection are presented. White light is used as a source, and oscillations of the detected light intensities are seen as a function of wavelength. The maximum and minimum of the oscillations can be used to determine scatterer size for monodisperse distributions of spheres when the refractive indices are known. In addition, several properties of the probe relevant to tissue diagnosis are examined and discussed including the effects of absorption, a broad distribution of scatterers, and the depth probed.

© 2001 Optical Society of America

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(170.7050) Medical optics and biotechnology : Turbid media

History
Original Manuscript: October 10, 2000
Revised Manuscript: March 21, 2000
Published: August 1, 2001

Citation
Murat Canpolat and Judith R. Mourant, "Particle size analysis of turbid media with a single optical fiber in contact with the medium to deliver and detect white light," Appl. Opt. 40, 3792-3799 (2001)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-40-22-3792


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. H. Jiang, J. Pierce, J. Kao, E. Sevick-Muraca, “Measurement of particle-size distribution and volume fraction in concentrated suspensions with photon migration techniques,” Appl. Opt. 36, 3310–3318 (1997). [CrossRef] [PubMed]
  2. H. Jiang, G. Marquez, L. V. Wang, “Particle sizing in concentrated suspensions by use of steady-state, continuous-wave photon-migration techniques,” Opt. Lett. 23, 394–396 (1998). [CrossRef]
  3. G. Balgi, J. Reynolds, R. H. Mayer, R. E. Cooley, E. M. Sevick-Muraca, “Measurements of multiply scattered light for on-line monitoring of changes in size distribution of cell debris suspension,” Biotechnol. Prog. 15, 1106–1114 (1999). [CrossRef] [PubMed]
  4. J. R. Mourant, J. P. Freyer, A. H. Hielscher, A. A. Eick, D. Shen, T. M. Johnson, “Mechanisms of light scattering from biological cells relevant to noninvasive optical-tissue diagnostics,” Appl. Opt. 37, 3586–3593 (1998). [CrossRef]
  5. A. M. K. Nillson, C. Sturesson, D. L. Liu, S. Andersson-Engels, “Changes in spectral shape of tissue optical properties in conjunction with laser-induced thermotherapy,” Appl. Opt. 37, 1256–1267 (1998). [CrossRef]
  6. A. H. Hielscher, J. R. Mourant, I. J. Bigio, “Influence of particle size and concentration on the diffuse backscattering of polarized light from tissue phantoms and biological cell suspensions,” Appl. Opt. 36, 125–135 (1997). [CrossRef] [PubMed]
  7. V. Backman, R. Gurjar, K. Badizadegan, I. Itzkan, R. R. Dasari, L. T. Perelman, M. S. Feld, “Polarized light scattering spectroscopy for quantitative measurement of epithelial cellular structures in situ,” IEEE J. Sel. Top. Quantum Electron. 5, 1019–1026 (1999). [CrossRef]
  8. L. T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J. M. Crawford, M. S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: a new technique for measuring nuclear size distribution,” Phys. Rev. Lett. 80, 627–630 (1998). [CrossRef]
  9. G. Franssens, M. de Maziere, D. Fonteyn, “Determination of the aerosol size distribution by analytic inversion of the extinction spectrum in the complex anomalous diffraction approximation,” Appl. Opt. 39, 4214–4231 (2000). [CrossRef]
  10. T. P. Moffit, S. A. Prahl, “In-vivo sized-fiber spectroscopy,” in Optical Biopsy III, R. R. Alfano, ed., Proc. SPIE3917, 225–231 (2000). [CrossRef]
  11. C. F. Bohren, D. R. Hoffman, Absorption and Scattering of Light by Small Particles (Wiley, New York, 1983).
  12. J. R. Mourant, T. M. Johnson, J. P. Freyer, “Characterizing mammalian cells and cell phantoms by polarized backscattering fiber-optic measurements,” Appl. Opt. (to be published).
  13. J. R. Mourant, J. Boyer, A. H. Hielscher, I. J. Bigio, “Influence of the scattering phase function on light transport measurements in turbid media performed with small source–detector separations,” Opt. Lett. 21, 546–548 (1996). [CrossRef] [PubMed]
  14. J. M. Schmitt, G. Kumar, “Optical scattering properties of soft tissue: a discrete particle model,” Appl. Opt. 37, 2788–2797 (1998). [CrossRef]
  15. M. Canpolat, J. R. Mourant, “High-angle scattering events strongly affect light collection in clinically relevant measurement geometries for light transport through tissue,” Phys. Med. Biol. 45, 1127–1140 (2000). [CrossRef] [PubMed]
  16. R. S. Cotran, V. Kumar, S. L. Robbins, Pathological Basis of Disease (Saunders, Philadelphia, Pa., 1994), Chap. 7.

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited