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Applied Optics

Applied Optics


  • Vol. 41, Iss. 22 — Aug. 1, 2002
  • pp: 4722–4731

Optoacoustic technique for noninvasive monitoring of blood oxygenation: a feasibility study

Rinat O. Esenaliev, Irina V. Larina, Kirill V. Larin, Donald J. Deyo, Massoud Motamedi, and Donald S. Prough  »View Author Affiliations

Applied Optics, Vol. 41, Issue 22, pp. 4722-4731 (2002)

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Replacement of invasive monitoring of cerebral venous oxygenation with noninvasive techniques offers great promise in the management of life-threatening neurologic illnesses including traumatic brain injury. We developed and built an optoacoustic system to noninvasively monitor cerebral venous oxygenation; the system includes a nanosecond Nd:YAG laser and a specially designed optoacoustic probe. We tested the system in vitro in sheep blood with experimentally varied oxygenation. Our results demonstrated that (1) the amplitude and temporal profile of the optoacoustic waves increase with blood oxygenation in the range from 24% to 92%, (2) optoacoustic signals can be detected despite optical and acoustic attenuation by thick bone, and (3) the system is capable of real-time and continuous measurements. These results suggest that the optoacoustic technique is technically feasible for continuous, noninvasive monitoring of cerebral venous oxygenation.

© 2002 Optical Society of America

OCIS Codes
(040.1880) Detectors : Detection
(110.7050) Imaging systems : Turbid media
(120.4290) Instrumentation, measurement, and metrology : Nondestructive testing
(170.1460) Medical optics and biotechnology : Blood gas monitoring
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine

Original Manuscript: October 1, 2001
Revised Manuscript: April 12, 2002
Published: August 1, 2002

Rinat O. Esenaliev, Irina V. Larina, Kirill V. Larin, Donald J. Deyo, Massoud Motamedi, and Donald S. Prough, "Optoacoustic technique for noninvasive monitoring of blood oxygenation: a feasibility study," Appl. Opt. 41, 4722-4731 (2002)

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