Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

Robust inference of baseline optical properties of the human head with three-dimensional segmentation from magnetic resonance imaging

Not Accessible

Your library or personal account may give you access

Abstract

We model the capability of a small (6-optode) time-resolved diffuse optical tomography (DOT) system to infer baseline absorption and reduced scattering coefficients of the tissues of the human head (scalp, skull, and brain). Our heterogeneous three-dimensional diffusion forward model uses tissue geometry from segmented magnetic resonance (MR) data. Handling the inverse problem by use of Bayesian inference and introducing a realistic noise model, we predict coefficient error bars in terms of detected photon number and assumed model error. We demonstrate the large improvement that a MR-segmented model can provide: 2–10% error in brain coefficients (for 2 × 106 photons, 5% model error). We sample from the exact posterior and show robustness to numerical model error. This opens up the possibility of simultaneous DOT and MR for quantitative cortically constrained functional neuroimaging.

© 2003 Optical Society of America

Full Article  |  PDF Article
More Like This
Volumetric diffuse optical tomography of brain activity

Joseph P. Culver, Andrew M. Siegel, Jonathan J. Stott, and David A. Boas
Opt. Lett. 28(21) 2061-2063 (2003)

Simultaneous integrated diffuse optical tomography and functional magnetic resonance imaging of the human brain

Xiaofeng Zhang, Vladislav Y. Toronov, and Andrew G. Webb
Opt. Express 13(14) 5513-5521 (2005)

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Figures (10)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Tables (1)

You do not have subscription access to this journal. Article tables are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Equations (19)

You do not have subscription access to this journal. Equations are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved