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Applied Optics

Applied Optics


  • Vol. 42, Iss. 16 — Jun. 1, 2003
  • pp: 3205–3214

Catheter for diagnosis and therapy with infrared evanescent waves

Brett A. Hooper, Anjul Maheshwari, Adam C. Curry, and Todd M. Alter  »View Author Affiliations

Applied Optics, Vol. 42, Issue 16, pp. 3205-3214 (2003)

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We have developed an optical delivery device (catheter) capable of transmitting broadband infrared light (IR wavelengths from 2 to 10 μm) for both diagnostic and therapeutic applications. The catheter is 1.68 mm in outer diameter and 1 m in length. It consists of two hollow glass waveguides coupled to a high-refractive-index optic tip. The IR light interacts with the tissue at the optic-tissue interface to measure the spectral signatures and perform therapy on the tissue at this interface. Fourier-transform IR spectrophotometer light is used to obtain the spectral signatures, and an IR free-electron laser (FEL) is used to study the therapeutic interaction of evanescent waves with the tissue. We present our catheter design; preliminary IR spectroscopy of aorta, blood, fatty tissue, and muscle; and IR FEL therapy on atherosclerotic aorta.

© 2003 Optical Society of America

OCIS Codes
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(170.1020) Medical optics and biotechnology : Ablation of tissue
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(230.7370) Optical devices : Waveguides
(240.6690) Optics at surfaces : Surface waves
(300.6340) Spectroscopy : Spectroscopy, infrared

Original Manuscript: August 30, 2002
Revised Manuscript: December 17, 2002
Published: June 1, 2003

Brett A. Hooper, Anjul Maheshwari, Adam C. Curry, and Todd M. Alter, "Catheter for diagnosis and therapy with infrared evanescent waves," Appl. Opt. 42, 3205-3214 (2003)

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  1. F. Mirabella, Internal Reflection Spectroscopy, Vol. 15 of Practical Spectroscopy Series (Marcel Dekker, New York, 1992).
  2. B. A. Hooper, Y. Domankevitz, C. Lin, R. Rox Anderson, “Precise, controlled laser delivery with evanescent optical waves,” Appl. Opt. 38, 5511–5517 (1999). [CrossRef]
  3. F. F. Jobsis, “Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters,” Science 198, 1264–1267 (1977). [CrossRef] [PubMed]
  4. W. J. Parsons, J. C. Rembert, R. P. Bauman, J. C. Greenfield, C. A. Piantadosi, “Dynamic mechanisms of cardiac oxygenation during brief ischemia and reperfusion,” Am. J. Physiol. 259, H1477–H1485 (1990). [PubMed]
  5. W. J. Parsons, J. C. Rembert, R. P. Bauman, J. C. Greenfield, F. G. Duhaylongsod, C. A. Piantadosi, “Myocardial oxygenation in dogs during partial and complete coronary artery occlusion,” Circ. Res. 73(3), 458–464 (1993). [CrossRef]
  6. M. Nilsson, D. Heinrich, J. Olajos, S. AnderssonEngels, “Near infrared diffuse reflection and laser-induced fluorescence spectroscopy for myocardial tissue characterisation,” Spectrochim. Acta Part A 51, 1901–1912 (1997).
  7. R. Manoharan, J. J. Baraga, R. P. Rava, R. R. Dasari, M. Fitzmaurice, M. S. Feld, “Biochemical-analysis and mapping of atherosclerotic human artery using FT-IR microspectroscopy,” Atherosclerosis 103(2), 181–193 (1993). [CrossRef]
  8. J. J. Baraga, M. S. Feld, R. P. Rava, “Detection of atherosclerosis in human artery by midinfrared attenuated total reflectance,” Appl. Spectrosc. 45, 709–710 (1991). [CrossRef]
  9. R. P. Rava, J. J. Baraga, M. S. Feld, “Near-infrared Fourier-transform Raman spectroscopy of human artery,” Spectrochim. Acta Part A 47, 509–512 (1991). [CrossRef]
  10. T. Arai, K. Mizuno, A. Fujikawa, M. Nakagawa, M. Kikuchi, “Infrared absorption spectra ranging from 2.5 to 10 μm at various layers of human normal abdominal aorta and fibrofatty atheroma in vitro,” Lasers Surg. Med. 10, 357–362 (1990). [CrossRef]
  11. W. Casscells, B. Hathorn, M. David, T. Krabach, W. K. Vaughn, H. A. McAllister, G. Bearman, J. T. Willerson, “Thermal detection of cellular infiltrates in living atherosclerotic plaques: possible implications for plaque rupture and thrombosis,” Lancet 347, 1447–1449 (1996). [CrossRef] [PubMed]
  12. P. Colarusso, L. Kidder, I. Levin, J. Fraser, J. Arens, E. N. Lewis, “Infrared spectroscopic imaging: from planetary to cellular systems,” Appl. Spectrosc. 52(3), 106A–119A (1998). [CrossRef]
  13. G. Edwards, R. Logan, M. Copeland, L. Reinisch, J. Davidson, J. Johnson, R. Maciunas, M. Mendenhall, R. Ossoff, J. Tribble, J. Werkhaven, D. O’Day, “Tissue ablation by a free-electron laser tuned to the amide II band,” Nature (London) 371, 416–419 (1994). [CrossRef]
  14. K. Awazu, A. Nagai, K. Aizawa, “Selective removal of cholesterol esters in an arteriosclerotic region of blood vessels with a free-electron laser,” Lasers Surg. Med. 23, 233–237 (1998). [CrossRef] [PubMed]
  15. D. R. Holmes, J. F. Bresnahan, “Interventional cardiology,” Cardiol. Clin. 9, 115–134 (1991). [PubMed]
  16. R. Linsker, R. Srinivasan, J. J. Wynne, D. R. Alonso, “Far-ultraviolet laser ablation of atherosclerotic lesions,” Lasers Surg. Med. 4, 201–206 (1984). [CrossRef] [PubMed]
  17. G. C. Hughes, A. P. Kypson, B. Yin, J. D. St. Louis, S. S. Biswas, R. E. Coleman, T. R. DeGrado, B. H. Annex, C. L. Donovan, K. P. Lanolfo, J. E. Lowe, “Induction of angiogenesis following transmyocardial laser revascularization in a model of hibernating myocardium: a comparison of holmium:YAG, carbon dioxide, and excimer lasers,” Surg. Forum 50, 115–117 (1999).
  18. C. A. Puliafito, R. F. Steinert, T. F. Deutsch, F. Hillenkamp, E. J. Dehm, C. M. Alder, “Excimer laser ablation of cornea and lens: experimental studies,” Ophthalmology 92, 741–748 (1985). [PubMed]
  19. J. P. Cummings, J. T. Walsh, “Erbium laser ablation—the effect of dynamic optical properties,” Appl. Phys. Lett. 62, 1988–1990 (1993). [CrossRef]
  20. J. Welch, M. Motamedi, S. Rastegar, G. L. LeCarpentier, E. D. Jansen, “Laser thermal ablation,” Photochem. Photobiol. 53, 815–823 (1991). [PubMed]
  21. E. D. Jansen, T. G. van Leeuwen, M. Motamedi, C. Borst, A. J. Welch, “Partial vaporization model for pulsed mid-infrared laser ablation of water,” J. Appl. Phys. 78, 564–571 (1995). [CrossRef]
  22. J. T. Walsh, T. H. Flotte, R. R. Anderson, T. F. Deutsch, “Pulse CO2 laser tissue ablation: effect of tissue type and pulse duration on thermal damage,” Lasers Surg. Med. 8, 108–118 (1988). [CrossRef]
  23. L. E. Busse, J. A. Moon, J. S. Sanghera, I. D. Aggarwal, “Mid-IR high power transmission through chalcogenide fibers: current results and future challenges,” in Lasers-Induced Damage in Optical Materials: 1996, H. E. Bennett, A. H. Guenther, M. R. Kozlowski, B. E. Newman, M. J. Soileau, eds., Proc. SPIE2966, 553–563 (1997). [CrossRef]
  24. Y. Matsuura, K. Matsuura, J. A. Harrington, “Power delivery of free-electron laser light by hollow glass waveguides,” Appl. Opt. 35, 5395–5397 (1996). [CrossRef] [PubMed]
  25. I. Gannot, A. Inberg, M. Oksman, R. Waynant, N. Croitoru, “Current status of flexible waveguides for IR laser radiation transmission,” IEEE J. Sel. Top. Quantum Electron. 2, 880–889 (1996). [CrossRef]
  26. H. Pratisto, S. Uhlhorn, E. D. Jansen, “Beam delivery of the Vanderbilt free-electron laser with hollow waveguides: effect of temporal and spatial pulse propagation,” Fiber Integr. Opt. 20, 83–94 (2001).
  27. Photran Inc., Amherst, N.H., www.photran.com .
  28. Remspec Inc., Charlton, Mass., www.remspec.com .
  29. Y. Matsuura, T. Abel, J. A. Harrington, “Optical properties of small-bore hollow waveguides,” Appl. Opt. 34, 6842–6847 (1995). [CrossRef] [PubMed]
  30. J. A. Harrington, “A review of IR transmitting, hollow waveguides,” Fiber Integr. Opt. 19, 211–227 (2000). [CrossRef]
  31. B. A. Hooper, G. C. LaVerde, O. T. von Ramm, “Design and construction of an evanescent optical wave device for the recanalization of vessels,” Nucl. Instrum. Methods Phys. Res. A 475, 645–649 (2001). [CrossRef]
  32. P. Klocek, ed. Handbook of Infrared Optical Materials (Marcel Dekker, New York, 1991).
  33. W. G. Driscoll, W. Vaughn, eds., Handbook of Optics (McGraw-Hill, New York, 1978).
  34. F. Kolodgie, A. Katocs, E. Largis, S. Wrenn, J. Cornhill, E. Herderick, S. Lee, R. Virmani, “Hypercholesterolemia in the rabbit induced by feeding graded amounts of low-level cholesterol,” Arterioscler. Thromb. Vasc. Biol. 16, 1454–1464 (1996). [CrossRef] [PubMed]
  35. E. V. Ross, Y. Domankevitz, R. R. Anderson, “Effects of heterogeneous absorption of laser radiation in biotissue ablation: characterization of ablation of fat with a pulsed CO2 laser,” Lasers Surg. Med. 20, 1–6 (1996).
  36. D. R. Kodali, D. M. Small, J. Powell, K. Krishna, “Infrared micro-imaging of atherosclerotic arteries,” Appl. Spectrosc. 45, 1310–1317 (1991). [CrossRef]

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