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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Vol. 44, Iss. 10 — Apr. 1, 2005
  • pp: 1798–1805

Fourier-domain holographic optical coherence imaging of tumor spheroids and mouse eye

Kwan Jeong, Leilei Peng, John J. Turek, Michael R. Melloch, and David D. Nolte  »View Author Affiliations


Applied Optics, Vol. 44, Issue 10, pp. 1798-1805 (2005)
http://dx.doi.org/10.1364/AO.44.001798


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Abstract

Fourier-domain holography (FDH) has several advantages over image-domain holography for optical coherence imaging of tissue. Writing the hologram in the Fourier plane significantly reduces background arising from reference light scattered from the photorefractive holographic film. The ability to use FDH is enhanced by the use of a diffuse target, such as scattering tissue, rather than specular targets, because the broader angular distribution from diffuse targets is transformed into a relatively uniform distribution in the Fourier plane. We demonstrate significantly improved performance for Fourier-domain optical coherence imaging on rat osteogenic sarcoma tumor spheroids and mouse eye. The sensitivity is documented at -95 dB.

© 2005 Optical Society of America

OCIS Codes
(030.6140) Coherence and statistical optics : Speckle
(070.2580) Fourier optics and signal processing : Paraxial wave optics
(090.0090) Holography : Holography
(170.1650) Medical optics and biotechnology : Coherence imaging
(190.5970) Nonlinear optics : Semiconductor nonlinear optics including MQW

Citation
Kwan Jeong, Leilei Peng, John J. Turek, Michael R. Melloch, and David D. Nolte, "Fourier-domain holographic optical coherence imaging of tumor spheroids and mouse eye," Appl. Opt. 44, 1798-1805 (2005)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-44-10-1798

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